Angiotensin II inhibitors with calcium channel blockers

Angiotensin II inhibitors with calcium channel blocking agents is a combination medicine containing both an angiotensin II inhibitor and a calcium channel blocker. This combination is often used to treat hypertension. The angiotensin II inhibitor stops the activation of the angiotensin II receptor which results in vasodilation, a reduction of aldosterone production and reduced vasopressin. These effects cause the reduction of blood pressure. Calcium channel blockers block calcium from entering cells of the heart and smooth muscle in the walls of blood vessels. This results in vasodilation of the arteries, a reduction in heart contraction force, a slowing of heart rate and a reduction in aldosterone production. These effects cause a decrease in blood pressure in the hypertensive patient and a decrease in symptoms in patients with angina or ischemic heart disease